Antidepressants in bipolar
Antidepressants are used cautiously in bipolar — on their own they can sometimes push toward a high or destabilize mood, so they're usually paired with a mood stabilizer, if used at all.
Antidepressants in bipolar disorder are used differently than in ordinary depression. In some people, taken without a mood stabilizer alongside them, they can turn a low into hypomania, mania or a mixed state — clinicians call this a switch — and in others they make episodes return more often.
That does not make them forbidden. Some people take one alongside a stabilizer and do well on it. What clinicians worry about is an antidepressant used on its own, and mixed states, where an antidepressant can make agitation and risk worse rather than better.
If an antidepressant seems to be speeding you up — less sleep, faster thoughts, more irritability — rather than lifting the low, report that quickly. Starting or stopping one is your prescriber’s decision, not something to try on your own.
See also
If you’re in crisis or thinking about harming yourself, you’re not alone and help is available right now. In the US & Canada call or text 988. In the UK & Ireland call 116 123 (Samaritans). Elsewhere, contact your local emergency services — Get Help Now lists lines by country.
One steadying step in your inbox each week
No overwhelm, no spam — just one helpful thing to help you feel steadier. Free.
📬 After you subscribe, check your spam or promotions folder for your welcome email (with the free PDF) — and add us to your contacts so it lands in your inbox.
No spam. Unsubscribe anytime. See our Privacy Policy.